Goals from Stephen Ireland, Roque Santa Cruz, Joleon Lescott, Carlos Tevez and Michael Johnson gave City a 5-1 win against Scunthorpe, although the visitors were level at one stage in the first period through Jonathan Forte.
Hughes said: "We have got virtually everyone back now. We have been able to rest players and the injured ones will be back for the weekend. We have a full complement of riches now to chose from, and we are delighted with the positives from this one."
He added: "We gave Roque Santa Cruz his first game, and he was excellent. He got a fine goal and his movement and awareness of people around him was first class.
"He will now grow into his role here. And we had Michael Johnson finally back after his injuries. The goal he scored showed the quality he has, and thankfully he is back fit and well.
"You can then see the talent he has. He has been really missed and we now want him in the side more regularly. He'll be like a new signing considering he's been out for over a year with various injuries.
Six of the top seven sides in the Premier League are in the last eight of the competition.
And Hughes added: "You just need to look at the quality of sides left in the tournament to know that clubs are now taking it more seriously.
"They are giving it more significance than they have done in the past. We made a statement right at the beginning that we would take it seriously and have a good run at it.
"We are now in the last eight with a lot of big clubs. We are in good shape, we are playing well and let's hope we get a good draw."