GMP have been heartened by recent goodwill gestures between City and United.
City officials laid a wreath at the memorial to the air disaster on their recent visit to Munich.
Goodwill gesture: Man City officials laid a wreath in Munich last month
However, there has been plenty of animosity amongst the fans too and GMP will be on high alert, both around Old Trafford and in the city centre and local pubs as they look to keep the peace.
'We want fans to enjoy themselves, but at the same time, we want to make it clear to the minority of fans who may be thinking of causing any trouble that we will clamp down hard on them,' said Chief Superintendent Mark Roberts from Greater Manchester Police's Trafford Division.
Warning: GMP will clamp down on any trouble
'Both Manchester United and Manchester City are supportive of the fact that anyone who is arrested in connection with causing trouble at the derby or in a related incident elsewhere this weekend, runs the risk of being banned from entering their respective clubs again in the future.
'The rivalry between the clubs really adds something extra to this fixture and should be embraced, but we must also ensure this is not used as an excuse by some fans to carry out football-related violence and disorder.'
Sir Alex goes racing. United boss Ferguson enjoys day at Doncaster ahead of derbyStrike one to Tevez! City rebel off the hook over alleged refusal to play in MunichAll the latest Man City news, features and opinionAll the latest Man United news, features and opinion