Moratti is likely to have to find a new coach for the Nerazzurri over the summer with Jose Mourinho on the brink of joining Real Madrid after leading the club to the Treble - a feat completed by Saturday's Champions League final victory over Bayern Munich at the Bernabeu.
Mancini, who guided Inter to three consecutive Scudetti before being dismissed in the summer of 2008 and replaced by Mourinho, led City to a fifth-placed finish in the Premier League six months after taking over at Eastlands.
When asked about how he intended to fill the post should Mourinho depart, Moratti told Sky Sport Italia: "I thought about it this morning.
"He (Mancini) is the only one I didn't think of due to the fact that we have already had him and he is part of our history.
"No, I don't think that for him this is the path to follow.
"I believe he is happy in England, that he likes living in England and hence, to bring him back in this difficult situation would be offensive."
Moratti did express admiration for Mancini, however.
"Both (Mourinho and Mancini) are very different from a character standpoint but they have something in common, courage," Moratti said.
"Both of them are courageous, because Mancini, I have to say, the great thing about Mancini, is that he was courageous and talented as a player and as a person.
"Mourinho has talent and courage as well as a professionalism that is born in his work ethic."
Mancini's former assistant at Inter and current Catania boss Sinisa Mihajlovic is among the leading candidates to take over.
Moratti said: "Mihajlovic certainly has character and is a fast learner.
"He is liked by the players. He is a friend of the players.
"We have a very good rapport with him but that doesn't mean that he could be the one chosen even though from a personal standpoint, it would be a choice I would like to make.
"Honestly, I have not decided yet."
Moratti says he will consider veteran coaches, and those cutting their teeth in the profession.
He added: "I am and will be more attracted towards an emerging coach but you have to find one that has new ideas.
"But perhaps a coach that knows through experience to maintain this group from a positive standpoint would be great."
The new man's first task will be to keep the current squad intact.
Saturday's hero Diego Milito - the Argentina international grabbed both goals to sink Bayern - has already been linked with a move to Madrid to link up again with Mourinho.
But Moratti insisted Milito would be staying in Milan.
"I only say one thing, there's a difference between Milito and our coach, Mourinho," Moratti said. "Mourinho has a clause in his contract by which if the clause is exercised, he can leave.
"However, Milito doesn't and hence, the discussion is over."
Milito was one of the players brought in last summer after Zlatan Ibrahimovic departed for Barcelona and the 30-year-old has been key to Inter's historic Treble-winning campaign.
In addition to his efforts against Bayern, he also scored the only goals in Inter's Coppa Italia final triumph over Roma, and in the club's Scudetto-clinching season finale at Siena.
Milito also nodded in a vital goal in the first leg of Inter's Champions League semi-final with Barcelona that the Italians won 3-1.
The South American is under contract with Inter until June 2013.