Barry suffered an ankle injury in Wednesday's home defeat to Tottenham and manager Roberto Mancini estimates it could rule Barry out for four weeks, placing his hopes of being fit for the World Cup in peril.
Ireland (ankle) will also miss out as City look for a victory that would confirm them in fifth spot.
Patrick Vieira looks likely to be handed a start alongside Nigel De Jong in midfield, while Shaun Wright-Phillips is also pushing for a starting berth.
Kick-off is at 4pm.
City (from): Nielsen, Fulop, Onuoha, Richards, Kay, Boyata, Kompany, Toure, Bridge, Garrido, Sylvinho, Adam Johnson, Cunningham, Zabaleta, De Jong, Vieira, Bellamy, Wright-Phillips, Tevez, Santa Cruz, Adebayor, Ibrahim, Nimely.