Rio Ferdinand (calf) and Jonny Evans (ankle) are both ruled out, meaning Smalling will partner Nemanja Vidic in the centre of United's defence.
Pressure: Smalling (right) will partner Vidic in defence for the Manchester derby
Javier Hernandez was the latest member of the Red Devils' international contingent to report back for duty, although given his arduous journey following Mexico's meeting with Bosnia, the best he can hope for is a place on the bench.
Team (from): Van der Sar, Lindegaard, Kuszczak, Rafael, O'Shea, Brown, Smalling, Vidic, Evra, Fabio, Nani, Fletcher, Carrick, Scholes, Gibson, Anderson, Park, Bebe, Giggs, Rooney, Berbatov, Hernandez, Owen.
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Explore more:People: Bebe, Rio Ferdinand, Nemanja Vidic, Nani Places: Manchester, Bosnia, Mexico