The Belgium international limped out of the first half of last night's Europa League victory over Aris Salonika with a hip injury and it is hard to see Kompany recovering quickly enough to be involved.
Substituted: Kompany (right) came off in the first-half against Aris
Kolo Toure could come in as a direct replacement, although Jerome Boateng is also capable of filling the void. Micah Richards (calf), James Milner (hamstring), Nigel de Jong and Adam Johnson (both ankle) are all expected to miss out.
Team (from): Hart, Taylor, Zabaleta, Boateng, K Toure, Kompany, Kolarov, Lescott, Wright-Phillips, Vieira, Y Toure, Silva, Barry, Tevez, Dzeko, Balotelli, Jo, Boyata.
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Explore more:People: Vincent Kompany, Kolo Toure, James Milner, Adam Johnson Places: Belgium