City will go into the game full of confidence after a fine weekend, with their own comfortable win over West Bromwich Albion given extra significance by title rivals United, Arsenal and Chelsea all dropping points.
City are now just five points behind the leaders, in the knowledge that United face the most testing of fixture lists between now and the end of the season.
Gunning for United: Milner clashes with Dimitar Berbatov during City's clash with United earlier this season
And Milner said: 'It's obviously amassive game. It's one everyone wants to win. It will be a tough gameand it's up to us to go there, perform and try and get a result.
'Weare confident and we have world-class players all the way through theside. We have younger players and older players and it's a good mixhere.
'They are a topteam, they have the experience of winning titles. They are looking todo that again and it's up to us to go and put a spanner in the works.
'Weknow we can keep improving and we will do that. We work hard intraining and we have great scope to go on and become even better. Ithink that's the main thing, to move forward as a team.'
One boost for City looks to be the form of Shaun Wright-Phillips, who has been offered the chance to step into the role vacated by the injured Adam Johnson.
Wright-Phillips looked bright and energetic during a late cameo appearance in the 3-0 victory against West Brom.
Hunting the title: James Milner in action against West Bromwich on Saturday
Only a week ago, former City academy player Wright-Phillips - who returned to Eastlands in 2008 after a spell with Chelsea - seemed be on on his way out of Eastlands but nothing materialised.
But with England star Johnson out for around three months with an ankle injury, the prospect of 29-year-old Wright-Phillips being involved regularly have improved.
City coach David Platt said: 'What we had prior to January was a squad, when all fit, of 24 or 25 players and Shauny found himself out of it a few times.
'It did not work out for him in terms of moving away but he is a consummate pro. He has trained exceptionally well as he has done all season. He gives you a lot of pace and attacking ability.
'We are not stupid enough not to realise he might be important to us between now and the end of the season.'
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Explore more:People: James Milner, Shaun Wright-Phillips, David Platt, Adam Johnson Places: United Kingdom