City boss Mark Hughes has spelt out his desire for silverware at the earliest possible opportunity and he recognises the value of the League Cup.
Having played full-strength sides in the previous two rounds, City will again be picking their strongest XI at Eastlands to tackle Scunthorpe.
The Iron have played at the City of Manchester Stadium before when they were on the end of a 3-1 defeat in 2006 for an FA Cup clash.
In total the two clubs have only played four times in their entire history - and on each occasion a big City win was witnessed.
Team newsCity go into the game undefeated at home this term and Hughes will have nothing but continuing that firmly in his mind, but he will have to do it without a fully fit squad to choose from.
Kolo Toure, Martin Petrov and Wayne Bridge are all struggling to shake off knocks, but Pablo Zabaleta is available after suspension.
Roque Santa Cruz remains doubtful after a bout of tonsilitis and may not be risked.
Scunthorpe go into the game with a number of players struggling with injury and boss Nigel Adkins admits a number of his squad are playing through the pain barrier.
One man who probably won't make the trip to Manchester is star striker Gary Hooper, who has a foot injury.
But one boost for Adkins is that defender David Mirfin should return from illness to feature.