Blackburn and Bolton have a number of players showing signs of the virus ahead of their Carling Cup matches.
And City defender Micah Richards was struck down while on holiday in Cyprus in the summer.
Hughes said: "What you find with Premier League clubs is that there are a lot of young, fit, energetic guys.
"If they do get it, they are only laid low for a couple of days. They soon get over it because they are fit and healthy and are not compromised too much.
"We have had experience of the illness already with Micah going down with it and we are quite happy with the things we have in place. We look at official guidelines and what is recommended in terms of any outbreak occuring."