Stoke have been rewarded for Sunday's FA Cup fourth-round win over Arsenal by being drawn against Barclays Premier League heavyweights Manchester City.
Tony Pulis' side pulled off the shock of the round by beating Arsene Wenger's side 3-1 at the Britannia Stadium.
They will now host City, who beat Scunthorpe, at Eastlands while the other big tie of the round sees Portsmouth travel to bitter south coast rivals Southampton.
The 2008 winners, who came from behind to beat Sunderland, will have to beat their neighbours at St Mary's to make it through to the last eight of the competition.
Draw in Full
Southampton v Portsmouth
Reading v West Bromwich Albion
Fulham v Notts County or Wigan Athletic
Chelsea v Cardiff City
Bolton Wanderers v Tottenham Hotspur or Leeds United
Derby County v Birmingham City
Manchester City v Stoke City
Wolverhampton Wanderers or Crystal Palace v Aston Villa