The average weekly pay at the Etihad Stadium is a staggering £100,764 which translates to an annual salary of £5,239,750.
City jump to top spot from third place last year, replacing Barcelona who are now fourth.
The LA Dodgers basketball team are second on the list, with their players averaging £93,380 per week, £4,855,783 annually.
Manchester United are in 12th place on the list, with average weekly wages of £75,423 (annual £3, 921,423). Last year they were 11th.
Relegated Wigan come in at 168th (£21,338 and £1,109,600).
Source: Manchester City MAD