Left-back Gael Clichy has also been ruled out with a minor knock while fellow defenders Micah Richards (hamstring) and Martin Demichelis (knee) are sidelined.
Striker Stevan Jovetic's involvement for Montenegro during the recent international break was curtailed by a hamstring problem but he is in contention to make his debut.
Stoke boss Mark Hughes has delivered promising news on the availability of a number of his players.
Kenwyne Jones, Glenn Whelan and Jonathan Walters picked up knocks during the recent World Cup qualifiers and international friendlies - but Hughes has confirmed that all three are in contention to feature against his former club.
Deadline-day acquisitions Marko Arnautovic and Stephen Ireland could feature, with Marc Muniesa (groin) the only definite absentee.
Stoke (from): Begovic, Sorensen, Cameron, Huth, Wilson, Shawcross, Wilkinson, Pieters, Whelan, Arnautovic, Ireland, Nzonzi, Assaidi, Adam, Palacios, Shea, Etherington, Pennant, Walters, Jones, Crouch.
Manchester City (from): Hart, Pantilimon, Zabaleta, Nastasic, Lescott, Boyata, Kolarov, Milner, Nasri, Navas, Fernandinho, Toure, Rodwell, Garcia, Dzeko, Aguero, Jovetic, Negredo.
Manchester City Fixtures .
Saturday September 1415:00 Stoke City v Manchester City
Sunday September 2216:00 Manchester City v Man Utd
Saturday September 2815:00 Aston Villa v Manchester City
Source: Manchester City MAD