Macclesfield boss Gary Simpson will be without Paul Bolland and Paul Morgan for the trip to Burton.
Midfielder Bolland is currently sidelined with a hamstring injury and skipper Morgan is out for the season with a broken arm.
The Silkmen have no other injury or suspension concerns as they bid to bid bounce back from Saturday's 4-0 home defeat at the hands of Stevenage.
Simpson said: "The most important thing for us is that we don't get too hung up on just the one game.
"Burton is going to be tough, they are fighting for their lives.
"Like ourselves they have been playing catch up and I'm sure they will have looked at their next two home games against us and Barnet with a view to picking up six points."