Macclesfield boss Gary Simpson will be without striker Vinny Mukendi for the trip to Gillingham.
Mukendi succumbed to an ankle injury while playing for Congo Under-19s in the Reze International Football Tournament over the Easter Weekend.
He is set be out for up to four weeks on the sidelines and therefore will not play again this season.
Midfielder Paul Bolland will also miss the last two games after undergoing surgery on his shoulder, which will rule him out of action for between six to eight weeks.
Silkmen skipper Paul Morgan is out for the season with a broken arm while midfielder Matt Hamshaw has been nursing a badly swollen ankle in training this week, although he is hoping to be passed fit.