Macclesfield boss Gary Simpson will assess Sam Wedgbury and Paul Bolland ahead of the trip to Morecambe.
Both men picked up injuries during Saturday's 3-3 draw at home to Torquay and are doubtful.
Defender Shaun Brisley could miss out again with a groin strain and striker Vinny Mukendi will be assessed as he bids to shake off a knee injury.
Fellow frontman Simon Yeo looks set to remain sidelined with a similar complaint as the Silkmen bid to put further daylight between themselves and the relegation places.
Simpson said: "We know it will be tough and we might have to shuffle things a little bit with injuries to Bolly and Wedge, and one or two looking a bit tired."