Paul Holland is expected to miss Macclesfield`s home clash against Southend on Easter Monday.
The midfielder was forced off after just 15 minutes of Saturday`s precious 1-0 victory at Cheltenham having dislocated a bone in his shoulder after falling heavily under a challenge.
Silkmen boss Gary Simpson rested defender Izak Reid and midfielders Hamza Bencherif, Sam Wedgbury and Lewis Chalmers to the bench at Whaddon Road and all four are firmly in contention to return against the Shrimpers.
Simpson said: "I made three or four changes with Monday in mind because we have two games coming up back-to-back, Southend come to the Moss Rose having picked up of late and with a day's extra rest."
Silkmen skipper Paul Morgan is out for the season with a broken arm.
Macclesfield go into Monday`s encounter knowing their League Two status will be assured if they better second-bottom Barnet`s result at home to Oxford.