Lyon lost precious ground in the race for Champions League qualification after a dismal 1-0 loss at Bordeaux on Sunday left them three points behind third-placed Lille, who have a game in hand.
Remi Garde's side won 1-0 at home to APOEL in the first leg of their Champions League last-16 tie on Tuesday, but they were toothless in attack at Stade Chaban-Delmas and were undone by a 41st-minute header from Yoan Gouffran.
Lyon's defeat -- their ninth of the season -- left them in fifth place, level on 39 points with Marseille, Rennes and Saint-Etienne, who romped to a 4-0 win at home to Rennes to steam into contention for a Champions League berth.
In Sunday's late game, Carlo Ancelotti faces his first major test as Paris Saint-Germain coach when the league leaders tackle second-placed Montpellier at Parc des Princes.
Montpellier trail PSG by only a single point and both teams are undefeated in all competitions in 2012, with Rene Girard's side still to concede a goal.
On Saturday, a 76th-minute Mathieu Debuchy strike gave Lille a 1-0 win at Lorient that strengthened the champions' grip on third place, eight points behind Paris.
Fourth-placed Marseille, who host Inter Milan in the Champions League on Wednesday, were held 1-1 at home by Valenciennes but they also have a game in hand on Lyon.