Luis Suarez will make his return from a 10-match ban in Liverpool's Capital One Cup third round at rivals Manchester United.
The 26-year-old's future has been the subject of rife speculation this summer after he began agitating for a move away from Anfield.
Should Suarez stay past next week's transfer deadline, his first match back after biting Chelsea defender Branislav Ivanovic last season will be at Old Trafford against United.
The clash is the pick of a third round to be played on September 24 or 25, when there will be a repeat of this year's FA Cup final.
Wigan shocked Manchester City to triumph in May and will travel to the Etihad Stadium hoping to cause another surprise in this year's Capital One Cup.
Jose Mourinho's first taste of the competition he twice won in his previous spell as Chelsea boss will be at League One outfit Swindon.
Holders Swansea kick-off their defence at Birmingham, while there are a number of all Premier League ties. Arsenal are at West Brom, Aston Villa host Tottenham and West Ham face Cardiff.
Newcastle's reward for sneaking past Morecambe tonight is a home clash with Leeds, while Sunderland take on Peterborough and Southampton welcome Bristol City.
Elsewhere, Tranmere travel to Stoke, Watford host Norwich, Hull welcome Yorkshire rivals Huddersfield to the KC Stadium and Leicester take on neighbours Derby.