The FIFA president is facing renewed demands for his resignation after dismissing on-pitch racism with an astonishing response.
In response to an earlier message from Blatter defending his position, Ferdinand hit back on Twitter on Thursday afternoon.
He posted: '@SeppBlatter to say what you said about racism in football spoke volumes of your ignorance to the subject.
Scroll down to watch the Blatter interview.
Hands up: Sepp Blatter is looking increasingly out of touch
A history of clangers from bumbling Blatter In 2004, the FIFA president said women players should 'wear tighter shorts and low cut shirts. to create a more female aesthetic.'
'I would say they (gay fans) should refrain from any sexual activities' - Blatter after being asked about the illegality of homosexuality in Qatar after they won the right to host the 2022 World Cup.
'I think in football there's too much modern slavery in transferring players or buying players here and there, and putting them somewhere.' - Defending the 'oppressed' Cristiano Ronaldo after his ?80m switch from Manchester United to Real Madrid.
In response to whether football had sexual inequality, he replied: 'There are gay footballers, but they don't declare it because it will not be accepted in these macho organisations. Look at women's football - homosexuality is more popular there.'
'We could make two halves four quarters' - In response to how 'soccer' could be more accessible to Americans.
'I have never seen Italy, Germany, Brazil or Argentina with a coach from another country. In fact, most of the best teams have a coach from their own country.' - Blatter's response to Fabio Capello's appointment as England boss.
'I guess you now have the full support of all the women, gay community + people against racism in football
'If we want 2 stamp out racism in society a football pitch is a good place to start-loved by billions of people around the world.'
Asked directly by a CNN reporter on Wednesday if racism exists on the pitch, Blatter denied it and said such incidents should simply be settled by a handshake at the end of the match.
'I would deny it,' he said. 'There isno racism, there is maybe one of the players towards another, he has a word or a gesture which is not the correct one, but also the one who is affected by that, he should say that this is a game.
'We are in a game, and at the end of the game, we shake hands, and this can happen. On the field of play sometimes you say something that is not very correct, but then at the end of the game you have the next game where you can behave better.'
To a reporter from Al-Jazeera he simply compounded the situation.
'Duringa match you may say something to somebody who is not exactly looking like you,' he said. 'But at the end. it's forgotten.'
It comes as Luis Suarez was charged by the FA over allegations that he racially abused Patrice Evra.
At the same time, England captain John Terry remains the subject of an FA inquiry and a formal Metropolitan Police investigation into claims that he racially abused Anton Ferdinand at Loftus Road last month.
Charged: It is claimed Suarez racially abused Evra last month
Under fire: Suarez has strenuously denied the claims