The Reds must take three points off Debrecen here in Budapest tonight and hope Fiorentina fail to beat Lyon to stand any chance of qualifying for the knockout stages.
Benitez will have Daniel Agger and Glen Johnson available after injury worries, while Yossi Benayoun is pressing to start after scoring in the 2-2 draw with Manchester City.
For many, however, the main action will be taking place 456 miles away in Florence but Benitez does not fear Liverpool will be the victims of any skulduggery.
With Lyon pressing to win Group E, he expects the French side to go all out for victory in Italy and wants the Reds to make sure they put themselves in a position to capitalise. Lyon are professionals and they will try to win,' said Benitez.
'All we can do at this moment is concentrate on our game and make sure what we need to do.
'The most important thing for us is to beat Debrecen. Nothing else matters.
'We can't think about what is going on anywhere else, as we can't change it.