The broadcaster holds rights to show 23 fixtures next season.
On Saturday August 14, the opening day, ESPN cameras will be at Stamford Bridge for Chelsea v West Brom (kick-off 5.30pm).
Newcastle v Aston Villa has been selected for Sunday August 22 (1.30pm) while Manchester United v West Ham completes the channel's line-up of live games for the opening month of the campaign (Saturday August 28, 5.30pm).
Sunderland v Arsenal is the Saturday evening game on September 18, with Bolton v Manchester United picked for the same slot the following weekend.
Manchester City v Newcastle will be shown on ESPN on Sunday October 3 (1.30pm), Aston Villa v Chelsea is the live game on Saturday October 16 (5.30pm) and a fortnight later, Manchester United v Tottenham is the network's Saturday evening fixture.
Two more matches have been picked for the same slot in November - Stoke v Liverpool on the 13th, and Liverpool v West Ham on the 20th.