Brendan Rodgers launched in to a tirade against referee Phil Dowd for his performance as Liverpool's eight-match unbeaten run came to an unfortunate end at Tottenham.
Spurs ran out 2-1 winners at White Hart Lane thanks to a stunning free-kick from Gareth Bale and Aaron Lennon's first half tap-in but Rodgers, whose team pulled a goal back courtesy of a Bale own goal, was infuriated at Dowd for not awarding them two spot-kicks.
"Nothing is going for us away from home, that's how its been all season in terms of decisions," Liverpool boss Rodgers said. "We should have had two [penalties tonight]. It's incredible to have gone through the season without getting a penalty."
He added: "The Steven Gerrard one was nearly assault. How is that not a penalty?
"Watch the second one. Luis Suarez spins, William Gallas swings his left foot, catches him and he goes down. The statistics will tell you that we've been in the box as much as anyone, but to arrive at this stage of season and not get a penalty."
Bale has now scored 10 goals for club and country this season - and Villas-Boas admits the biggest teams on the planet will have been alerted by the winger's form.
"Tottenham as a club want to keep him here as long as we can but we understand players like this have propositions, have market which is the nature of the game," the Spurs boss said.
"At the moment he's doing extremely well for Spurs and we are absolutely amazed with what he can do for us. Hopefully, we have no doubt he can become a top player in the future. He is on to a great career."
Reina was powerless to stop the ball as it dipped and swerved in to the net for Tottenham's first and Bale nearly beat the Liverpool stopper twice more from similar range.
"Ronaldo showed you can almost hit the ball from the bottom to the top and it has an effect it changes direction," Villas-Boas said. "Gareth has the power to hit the ball at that pace and that's why the ball gets so many effects."