Liverpool midfielder Jay Spearing faces up to six weeks on the sidelines after suffering an ankle injury in training.
The 21-year-old had hoped to use the absence of Steven Gerrard and Lucas Leiva to make his first Barclays Premier League start against West Ham on Saturday, but he sustained an injury at the end of Friday's training session to add the Reds' injury concerns.
"Unfortunately, right at the end of the training session, which was five-a-side and not at all a competitive game, he turned his ankle and cracked a small bone just above the ankle in his fibia," Liverpool boss Roy Hodgson told the club's website. "That means he is going to be missing for six weeks. It is a terrible blow for Jay and us."
He added: "He has been doing ever so well and getting closer and closer to a place in the first team.
"I was considering using him in this game, possibly even starting him."