Leyton Orient are without central defenders Ben Chorley and Terrell Forbes who were both sent off against Droylsden in the FA Cup.
Aaron Brown and Brighton loanee Andrew Whing are set to deputise.
Tranmere Rovers manager Les Parry told BBC Radio Merseyside: "Two wins would see us get into the top half of the division and the way things are going, somebody is going to put some wins together and pull away at the top.
"We've just got to make sure that we hold onto the tailcoats of the sixth [placed] team.
"Most teams in our division play in a similar fashion, the only thing you can look at is individuals that can hurt you."