Alex Revell has been ruled out of Leyton Orient's clash with Southampton.
The 14-goal striker left the field on a stretcher after falling awkwardly during the first half of Tuesday's win over Plymouth and is facing a spell on the sidelines.
Jonathan Tehoue came on for Revell and could be in line for a start alongside veteran Scott McGleish, who scored his 201st career goal against Argyle.
Centre-half Ben Chorley remains a doubt having missed the last two matches with a thigh problem and midfielder Matthew Spring serves the final game of a three-match ban for his red card against Yeovil.
The Os are three points off the play-offs and have a game in hand on sixth-placed Bournemouth.