Leyton Orient will check on Ben Chorley ahead of the clash with Plymouth.
The centre-half missed Saturday's 3-1 defeat at Charlton due to a thigh problem and will be assessed prior to kick-off.
Midfielder Matthew Spring is still missing as he serves the second game of the three-match ban he received for a red card against Yeovil last weekend.
Skipper Stephen Dawson (dead leg) and left-back Charlie Daniels (ankle) were carrying injuries ahead of the weekend but both came through the full 90 minutes unscathed.
Back-to-back defeats have put a big dent in Orient's play-off hopes so boss Russell Slade could make changes with Paul-Jose Mpoku and Adam Chambers pushing for places in the starting line-up.