Leyton Orient boss Russell Slade could be without striker Scott McGleish for the trip to Carlisle.
McGleish sustained an injury and was replaced by Jonathan Tehoue after just 31 minutes of the 2-1 home win over Peterborough on Good Friday.
The frontman will be assessed but skipper Stephen Dawson was passed fit for the victory over Posh after recovering from a back injury.
Defender Ben Chorley remains a doubt with the thigh injury which has sidelined him since last month, midfielder Jimmy Smith could miss out again with a knee problem and winger Paul-Jose Mpoku is struggling with an ankle knock.
Striker Alex Revell will miss the clash and is unlikely to play again this season due to knee ligament damage.