Sunderland youngster Michael Liddle will be one of a host of debutants in the Leyton Orient line-up for the trip to Yeovil.
Liddle was this week drafted in on loan as cover for Charlie Daniels, who is out for a couple of weeks with a knee injury, and is set to go straight in at left-back.
Midfielder Adam Chambers is the only other injury concern after taking a whack to the head in training on Tuesday but he is expected to be fine.
French striker Jonathan Tehoue missed much of pre-season with a hamstring injury but he is fit again.
Midfielder Stephen Dawson, the summer signing from Bury, will wear the captain's armband while Alex Revell, Terrell Forbes, Aaron Brown, Elliot Omozusi, Dean Cox and Matthew Spring will also be among the new faces on show.