Preston manager Darren Ferguson could be without defender Wayne Brown, who suffered a hamstring injury against Coventry City on Saturday.
On-loan Manchester United pair Matt James and Josh King will again miss out with ankle injuries.
MATCH PREVIEW Having made their worst start to a season since 1923, Preston ended a four-match run of defeats with a morale-boosting win at Coventry City on Saturday.
They will be hoping that victory signals an upturn in their fortunes. North End have lost six league matches this season - more than any other Championship side - and the last four of those defeats have all been by a single goal.
Leeds, who have not lost at home to Preston for almost half a century, are fifth in the table and chasing a fifth win in seven league outings. They have kept clean sheets in their last two games and have won their last two home matches.
The Yorkshire side have also conceded four goals in the final 15 minutes of Championship games this season, which is more than any other team. Preston, meanwhile, are the only side in the division yet to score in either the first or last 15 minutes of a match.
MATCH FACTS Head-to-head
• Preston have won 21 and Leeds 13 of the of the 42 previous league matches between these clubs, of which eight have been drawn.
Have your say on this match • North End have drawn two and lost three of their five league trips to Elland Road since winning there 2-1 in the old Second Division in September 1961.
• A clean sheet for Leeds would mean three consecutive shut-outs for the first time since December last year.
• Leeds have rescued an unrivalled seven points from Championship matches this season after going behind.
• Preston are one of only two teams in the second tier yet to draw a league game this term. The other is Swansea.
• A win would mean back-to-back victories for North End for the first time since January, and for only the second time under manager Darren Ferguson.