Victory over Swindon on Saturday would clinch Leeds a seventh consecutive home success, last registered by the Whites when they were in the Premier League following a 2-1 triumph over Leicester on Boxing Day 1999.
Ankergren said: "It's another crucial game for us and if we want to stay
in the top six it's another must-win game. But we can only win these games through hard work and by keeping our focus."
Jermaine Beckford's hat-trick against Yeovil in midweek inspired Leeds to a sixth successive home league win for the first time since the 2005/06 season - and Ankergren believes Grayson's side must take maximum points from all five of their remaining home matches.
The Dane added: "It was one of those games against Yeovil that we needed to win if you want to be up there.
"All in all it was another good game for us and that's six successive home wins. We must win all our games at home, even if we know it's not always going to be easy."