Leeds will be without midfielder Neil Kilkenny for the clash at Cardiff.
The midfielder has joined up with the Australia squad ahead of the Asian Cup and could be absent for a month.
Ross McCormack replaced Kilkenny, who started on the substitutes' bench, in the New Year's Day draw with Middlesbrough and is expected to continue.
George McCartney has returned to Sunderland following the end of his loan spell so Andrew Hughes is expected to continue at left-back, although Ben Parker and Fede Bessone provide manager Simon Grayson with alternative options.
Andy O'Brien, who has signed a permanent deal with Leeds after his loan spell from Bolton, is likely to continue at the heart of defence alongside Neill Collins, but Grayson could be tempted to rest some of his players who appeared to be off the pace against Middlesbrough.
Lloyd Sam, Sanchez Watt, Billy Paynter, Alex Bruce and Davide Somma are all vying for starting places as Leeds bid for a first win in four matches after three successive draws.