Champions Juventus underlined their Serie A title credentials by going top as Inter Milan were humbled 3-1 by a Francesco Totti-inspired Roma at the San Siro on Sunday.
AC Milan, who finished runners-up to Juventus last season but stuttered against Sampdoria last week, got their scudetto campaign back on track Saturday when Giampaolo Pazzini struck a hat-trick in a 3-1 win away at Bologna.
In Sunday's earlier match Juventus produced a similarly commanding performace in a 4-1 win away to 10-man Udinese which included a brace from Sebastien Giovinco and gave them two wins from two.
The bulk of the Serie A programme was held over for Sunday night, and while there were deserved wins for Napoli and Lazio, Roma's humbling of Inter Milan at the Olympic stadium was the talk of the night.
After 15 minutes former Italy marksman Totti was given space on the left and delivered a perfectly-weighted cross for Alessandro Florenzi to head superbly past the outstretched Luca Castellazzi and into the bottom corner.
Inter striker Diego Milito twice came close with a header on the half hour and an angled shot five minutes before the interval that was blocked by a defender.
And after the restart Inter, who hammered promoted Pescara 3-0 away last week, got back on level terms albeit in somewhat fortuitous fashion.
Antonio Cassano, who until last week had been AC Milan's main striker, latched onto a a long ball from Dutchman Wesley Sneijder, turned while holding off two defenders and saw his deflected shot rise high and drop into the goal.
His celebrations, less than an hour after being left out of Casare Prandelli's most recent Italy squad, were exuberant but were soon overshadowed.
Roma striker Daniel Osvaldo, who was red-carded for a second bookable offence late in the match, missed two great chances to put Roma ahead while in prime position to score.
But his vision and sense of good timing finally paid off when he beat Inter's failed attempt to spring the offside trap and ran onto a Totti long ball to chip the onrushing Castellazzi.
Inter's hopes of launching any kind of fightback were extinguished nine minutes from time when Osvaldo's chip with the outside of his right boot from the left flank allowed second-half substitute Marquinho to somehow beat the diving Castellazzi from the tightest of angles.
Earlier, Juventus capitalised on the early expulsion of goalkeeper Zelijko Brkic to hit four past Udinese in a 4-1 win at the Stadio Friuli.
After Brkic was sent off for a foul on Sebastien Giovinco, Chilean midfielder Arturo Vidal slammed the penalty past replacement 'keeper Daniele Padelli.
Montenegrin Marko Vucinic made it two just before the interval after scoring from Ghanaian debutant Kwadwo Asamoah's square ball on the edge of the area.
Giovinco then produced a double in the latter stages while the Bianconeri grabbed a consolation goal through Andrea Lazzari after a mix-up in the Juventus defence.
While Antonio Conte's side sit top on six points, they are being trailed closely by Napoli (6) and Lazio (6), while Sampdoria's 2-1 win over Siena left the Genoese in third with five points.
Czech midfielder Marek Hamsik opened the scoring for Napoli after heading home a free-kick and Swiss defender Blerin Dzemali made it two with 15 minutes remaining.
Fiorentina grabbed a goal back in the final minutes when Stevan Jovetic produced a superb strike.
Germany international Miroslav Klose, meanwhile, turned in a sublime performance scoring a brace either side of a superb goal by Italian midfielder Antonio Candreva to give Lazio in a 3-0 home win over Palermo.