Winger Edwards and midfielder Grant Leadbitter were both signed from Keane's former club Sunderland on transfer deadline day for a combined fee in the region of £4million, while Rosenior arrived on loan from Reading.
Rosenior will start at right-back, with Leadbitter expected to partner another Sunderland recruit Jack Colback in midfield.
Edwards, however, has been away from the club since signing on international duty with Trinidad & Tobago and a late decision will be made on his availability.
Keane remains without a trio of players who are recovering from knee injuries.
Luciano Civelli hopes to be back before Christmas and David Norris is out until January, but left-back Thatcher could be back within several weeks.