Ipswich manager Roy Keane must decide whether to keep faith with teenage striker Connor Wickham at Reading.
The 17-year-old gave the ball away in the build up to Scunthorpe's opener on Saturday and was immediately replaced by Keane as he switched to a 4-1-4-1 formation after just 32 minutes.
Wickham could be back on the bench at the Madejski as midfielder Luke Hyam was impressive after replacing him.
Jaime Peters will also be hoping for a recall at right-back after the Canadian came off the bench to score the equaliser at Glanford Park.
Tottenham midfielder Jake Livermore was an unused substitute on Saturday and will be hoping for his Town debut but Luciano Civelli will be absent again as he continues to recover from a serious knee injury.