Jakupovic in Cup return for Tigers
Hull goalkeepers David Stockdale and Mark Oxley are both ineligible for the FA Cup clash with Barnsley.
Stockdale has returned for a second loan spell with the Tigers but has not been given permission to play by parent club Fulham, while Oxley, on loan from Burton, has already appeared for the npower League Two side in the competition.
Swiss goalkeeper Eldin Jakupovic is therefore expected to return to the starting line-up.
Manager Steve Bruce has no new injury or suspension problems, but leading goalscorer Sone Aluko remains sidelined with a slight tear in his Achilles.
Forward Matty Fryatt (Achilles) and defender Joe Dudgeon (knee) remain long-term absentees.
Bruce made several changes to his line-up for the third round tie against Leyton Orient and could be tempted to rest some of his players against Barnsley.
Barnsley will be without midfielder Stephen Dawson, but Jim O'Brien could return to contention.
Dawson suffered serious ankle ligament damage in last week's draw at Ipswich and has been ruled out for up to eight weeks, so Kelvin Etuhu, who replaced the Irishman at Portman Road, is hoping to keep his place.
Winger O'Brien missed out last week after sustaining a dead-leg in the recent win over Leeds and is rated 50/50.
Defender Jim McNulty was also absent against Ipswich after tweaking a hamstring in training and is still struggling.
Manager David Flitcroft, who has won two and drawn one of the four games in which he has taken charge since Keith Hill's sacking last month, must decide whether to leave striker Danny Rose on the substitutes' bench.
Teenager Rose, who has scored twice in his last three appearances, is pushing for only his third start for the Reds and his first of the season.
Defender Bobby Hassell is also pushing for a recall to the side.