Brown, back playing and scoring after a lengthy injury absence, did not feature in Pools' Carling Cup defeat to Burnley in midweek as a precaution after taking a knock to his knee against Gillingham.
The exciting forward, who scored a stunning winner at Priestfield, should resume his promising partnership with Denis Behan.
Midfielder Ritchie Jones suffered a broken hand against the Gills but played 120 minutes of Tuesday's game wearing a protective cast and he should keep his place.
Jon-Andre Fredriksen could come back into the starting line-up after a substitute's role against the Clarets, while Colin Larkin looked lively off the bench and is pushing for a more prominent role.
Iceland international Armann Bjornsson is in contention following his free transfer switch from SK Brann this week, while Ben Clark could make the bench after a quicker-than-expected return from surgery on a hernia.