Inverness have not lost a league game on the road in 12 months, while Accies have picked up just one point at home so far this season and sit bottom of the SPL ahead of the weekend action.
But Reid has backed his players to upset the odds and claim a much-needed win in front of their own fans - if they can hit top form on the day.
"Records are there to be broken," he said.
"We are the home side and we are really disappointed in just picking up one point at home.
"That tells you where our problems lie at the moment. But, if we play to our potential we will win the game, that I guarantee.
"We want to make sure we give no presents away because we have been giving too many away in recent weeks.
"We have already gone to Inverness and won so there is no reason why we can't win again.
"We had them watched against Aberdeen, who were a bit unfortunate on the night not to take something from the game.
"But that seems to be the way things are going for them as well at the moment."
Accies came out on top against Inverness back in August when former Caley Thistle player Dougie Imrie grabbed the only goal of the game.
Reid added: "Their record away from home is obviously far superior than their home form.
"But, in terms of personnel, there is not a lot between the two teams.
"Jonny Hayes is a big, big player for them. He is a player I admire and he is a talented lad. If we can keep him quiet, then we can win the game."
Newly-promoted Inverness sit fifth in the SPL, with 18 points on the board already this term.
Asked if he thought they have surprised a few people, Reid said: "I think they might have surprised themselves with the amount of points they've got, to be honest.
"It's fantastic to come up and have that amount of points.
"Things are going for them and they are working hard as a unit, as you would expect of Inverness, and they've got goals in their team.
"In terms of points, they have done really well."
In contrast, Accies sit rock bottom but their manager is not panicking just yet.
"This is our third year in the SPL and it's always been really tight and it's going to be tight at the bottom again," said Reid.
"We are at the bottom of the pile at the moment and there is only one way we can go and that's up the way.
"I remain positive, I've got a belief in what we are doing at the club and we will bounce back."