Coach Milovan Rajevac is confident Ghana can deal with the pressure of attempting to become the first African side to reach the World Cup semi-finals.
Ghana take on Uruguay in Johannesburg on Saturday after overcoming the United States in their last-16 match.
Rajevac said: "We are not thinking about the pressure. We played very well at the African Nations so we have already proved that we are a team that knows how to compete. We will try to relax. You know it is good for us to be here. We are very happy with the whole situation."
He added: "We have no obligation but still we want to use this opportunity to do our best and to make history.
"We have a lot of new players but they are all growing in confidence and they are all doing their best.
"The unity of the team is the most important quality we have. We just take one match at a time and try to do our best.
"Of course, sometimes you feel a little pressure. This is the highest level there is but we just try to do our best every match. We give the maximum."
Rajevac insists Ghana will not alter their style to combat the threat of Diego Forlan, who has been in sparkling form for Uruguay.
He said: "Uruguay have been very impressive. They are a South American nation with players playing in the best leagues in Europe.
"They have to be one of the best teams in the world. They deserve every respect and Forlan is a fine player. But we will play the way that has brought us success so far. We are not going to adjust our style and we will try to use whatever weakness we can find in our opponents."