Diomansy Kamara believes a win against Roma would virtually secure Fulham a place in the knock-out phase of the Europa League.
Fulham currently top Group E two games into the competition with the leading sides in each group joining eight third-placed teams from the 2009-10 UEFA Champions League group stage in the next round.
The 28-year-old has come up against Roma in the past while in Italy with Modena and has success against them having scored home and away against the Giallorossi.
"I know Roma as I played against them when I was with Modena in Italy," he said. "I scored against them as well, so I hope I play again and score too.
"I scored against them both in the Olympic stadium and when Modena were at home. I know Roma and they are a really good team. This is a good omen for us.
"Roma, Basle and Sofia have all lost in the group so far. Only we haven't lost, so maybe if we win this game we go through to the next round of the competition."
Fulham have yet to hit the dizzy heights of last season's seventh placed finish, although Monday's 2-0 success over Hull City has lifted Roy Hodgson's side into 12th.
Zamora believes the quality of Fulham's opposition needs to be taken into consideration having played three of the top six sides already in the new campaign.
"We've played some good football but remember so far we've faced Arsenal, Chelsea and Aston Villa and that is never easy in the first eight games," he continued.
"Twelfth in the table is all right for Fulham. If you finish in that position at the end of the season it's okay.
"It won't be easy to finish seventh again when you see the money teams like Tottenham, Aston Villa and Man City have spent."
Former Fulham hero Jimmy Bullard made his return following a long-term injury for Hull City on Monday and Kamara was surprised by the poor reception he received.
"I am happy to see Jimmy back because he is a good guy who did well for Fulham.
"He loved the supporters and I didn't understand why they booed him. He did well for Fulham.
"I hope he has a good season for Hull."
Brothers reunitedMeanwhile, Thursday's clash between Fulham and Roma sees Bjorn Helge Riise take on older brother John Arne for the very first time.
Bjorn Helge insists his brother has always got one over him in the past, although he hopes for a change of fortunes at Craven Cottage.
"We talk every day on the phone and in the national team we share a room," explained Riise. "I've never played against him before.
"He told me he is going to smash me and I am going to smash him. I am little brother and have always lost against him in everything.
"I used to run as fast as I could to get home to my mum because I knew then he couldn't touch me."