All eyes will be on the Red Devils to see if they can bounce back from the humiliation heaped on them by rivals Liverpool after the 4-1 defeat last weekend.
United still have a four point cushion over their rivals, with the added insurance of a game in hand, but their capitulation in their last outing will have the Cottagers believing they can cause an upset.
Roy Hodgson's men ended a run of two straight defeats at Craven Cottage in the league, having lost just once at home previously, by picking up their first away win of the season when they triumphed 3-1 over Bolton last Saturday.
Fulham team newsHodgson will know all about United after their previous two encounters and after conceding seven goals in those two games, four in the last meeting in the FA Cup, the former Inter boss may opt for a more cautious approach.
A switch from their usual 4-4-2 formation to a more compact 4-5-1 is a possibility with striker Bobby Zamora likely to miss out if he decides on the latter.
Fellow striker Diomansy Kamara is pushing for a start after making several appearances from the bench in recent weeks, as he has now fully recovering from a knee injury which has sidelined him since the summer.
The Senegal international netted the third against Bolton last time out to claim his first goal of the season and is an option up front.
Defender Aaron Hughes was substituted late on in the 2-1 defeat to Blackburn last week and was a doubt for the clash at the Reebok.
But the Northern Irish international came through the 90 minutes last weekend unscathed and is set to start again.
Man United team newsDefender Nemanja Vidic will have to wait a while longer to erase the painful memories of last Saturday as he misses the match through suspension after picking up a red card against Liverpool.
The 27-year-old will miss two Premier League games, the other being Aston Villa next week so Jonny Evans should come in.
Defenders Wes Brown (foot) and Rafael Da Silva (ankle) remain sidelined with the Brazilian expected to be back training within ten days.
Fellow right-back Gary Neville has recovered from his injury and is back in the squad and could feature.
After a disappointing showing last weekend midfielder Anderson could find himself back on the bench, with Darren Fletcher stepping in to replace him.
Striker Dimitar Berbatov should also come back into the starting line-up after coming off the bench last time out. Carlos Tevez is most likely to be the one to make way.
Possible starting XI's:
Fulham: Schwarzer, Pantsil, Konchesky, Hughes, Hangeland, Davies, Dempsey, Murphy, Etuhu, Zamora, Johnson.
Man Utd: Van der Sar, O'Shea, Evra, Ferdinand, Evans, Giggs, Ronaldo, Park, Fletcher, Berbatov, Rooney.