Djibril Cisse has been ruled out of the World Cup after breaking his right leg during France's 3-1 friendly victory against China on Wednesday.
The Liverpool striker lasted just 11 minutes of the match before being stretchered off following a collision with China captain Zhi Zheng.
After the game Les Bleus coach Raymond Domenech revealed: "Cisse went straight to the hospital where he is currently being operated on. He has an open fracture of the tibia.
"It's a vicious blow to all of us."
An official from the French Football Federation added that Cisse had also broken his right fibula.
The news will come as a major blow to the 24-year-old who missed six months of the 2004-05 campaign after suffering a broken left leg during a Premiership game against Blackburn Rovers.
Fenerbahce's Nicolas Anelka and Barcelona's Ludovic Giuly are in line to replace Cisse in the France squad, but Domenech has not yet turned his thoughts to who to call up.
He added: "We don't know the name of his replacement yet, we want to take our time in order to make the right decision. This is a big shock and a huge trauma for the team."
Cisse's injury overshadowed another lacklustre display by France.
Zinedine Zidane missed an early spot-kick before David Trezeguet opened the scoring after 31 minutes, only for Zheng Zhi to level from the penalty spot midway through the second half.
The game looked set to end in a draw until Wang Yun put through his own goal in the 89th-minute and Thierry Henry capitalised on a goalkeeping error in stoppage-time to secure victory.