Defender Christian Ribeiro set to return for Exeter
Exeter should be able to welcome back Christian Ribeiro for the visit of Oxford.
The defender suffered minor concussion during the 2-0 defeat by York last Tuesday and missed Saturday's 1-1 draw against Newport as a precaution.
Midfielder Ryan Harley has played the last two matches since returning from a hip injury and could be rested.
The clash is a milestone for long-serving boss Paul Tisdale as it will be his 500th competitive match in charge.
Oxford have injury concerns with top scorer Kemar Roofe struggling due to a groin problem.
Ryan Taylor, Jake Wright and Jordan Evans are sidelined while boss Michael Appleton has a host of new knocks to deal with after Saturday's defeat by Accrington.
Appleton has not revealed who the latest injury doubts are, but he is likely to have to name a youthful bench.
The U's remain in the automatic promotion places despite losing their last two matches.
Source: PAR