Exeter are set to be without Luke Croll for Newport's Sky Bet League Two visit.
Defender Croll was carried off in the early stages of Exeter's 3-1 Checkatrade Trophy defeat to Yeovil on Tuesday.
Jayden Stockley, who had a successful loan spell at Exeter in 2016, could make the bench after returning to the Grecians from Aberdeen on transfer deadline day, along with midfielder Hiram Boateng who has signed from Crystal Palace on a free transfer.
Teenage right-back Kane Wilson, signed on loan from West Brom along with striker Kyle Edwards, will link up with his new team-mates next week after international duty with the England Under-18 squad.
Newport made eight changes for their midweek Checkatrade Trophy defeat at Forest Green and it will be a similar amount in Devon.
Defender Mark O'Brien should return after being forced off during last Saturday's 4-1 defeat of Chesterfield with a slight hamstring strain.
While captain Joss Labadie and forwards Shawn McCoulsky and Lamar Reynolds are doubtful.
Striker Marlon Jackson is still ruled out by a hamstring injury.