The Belgium international is serving the second match of a three-game suspension for his sending off against Bolton earlier this month.
Straight red: Fellaini (left) was dismissed against Bolton Wanderers
Manager David Moyes has reported no fresh injury concerns following this week's midweek internationals.
That leaves Leon Osman (ankle), Victor Anichebe (knee) and Ross Barkley (broken leg) as the only major absentees.
Provisional squad: Howard, Neville, Distin, Jagielka, Baines, Coleman, Cahill, Pienaar, Heitinga, Arteta, Saha, Rodwell, Yakubu, Bilyaletdinov, Beckford, Gueye, Hibbert, Baxter, Duffy, Mucha.
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Explore more:People: Leon Osman, Victor Anichebe, David Moyes Places: Belgium