Everton's new signing Lars Jacobsen will be sidelined for up to four months after dislocating his shoulder while on international duty.
The 28-year-old summer signing from Nurnberg was substituted at half-time during Denmark's 3-2 victory over Portugal in Lisbon.
Jacobsen has yet to make his debut for the Toffees following his arrival on a free transfer but had been expected to make his bow in Saturday's Premier League meeting with Stoke City.
However, Toffees boss David Moyes told the club's official website: "We didn't get good news on Lars. He'll need an operation that will keep him out for three or four months.
"It's a blow to the boy, and we've had a few injuries, which is part of football. He was just beginning to settle in and we were looking forward to using him."
In addition, Tim Cahill, Steven Pienaar, Louis Saha and Tony Hibbert are all still sidelined.
Meanwhile, Moyes has confirmed that news about his new contract is imminent.
He said: "I think things are moving along nicely and hopefully we'll have some news shortly."