The England international aggravated a thigh strain on his return to action in Saturday's loss at Stoke and will also miss next weekend's FA Cup tie at Scunthorpe.
Hazard: Jagielka has scored two own goals in recent weeks
John Heitinga (knee) could replace him if he passes a fitness test but winger Seamus Coleman is also doubtful after a blow to the ribs.
Top goalscorer Tim Cahill is on international duty with Australia at the Asian Cup.
Provisional squad: Howard, Neville, Hibbert, Heitinga, Distin, Baines, Coleman, Pienaar, Osman, Rodwell, Fellaini, Arteta, Bilyaletdinov, Saha, Yakubu, Beckford, Anichebe, Gueye, Baxter, Duffy, Mucha.
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Explore more:People: Tim Cahill, Phil Jagielka Places: United Kingdom, Australia