Teenager Tom Cairney equalised with a superb volley but Arteta slotted a fine second before an own goal from Richard Garcia made it 3-1 to the hosts.
Landon Donovan came off the bench and slammed in a fourth before Jack Rodwell completed another fine move to seal it.
All that means the Tigers are still without an away win in the league this season and well and truly failed to put down the marker demanded by manager Phil Brown.
But the day belonged to Everton, and Arteta in particular.
'Dominant' Everton delight Moyes
The goals were the Spaniard's first since returning from injury and served as a timely reminder of his quality and importance to Everton's cause.
The victory - a sixth in succession at home - equals a club record in the Premier League and lifts the Toffees up to eighth, four points behind Aston Villa.
The game was not as dramatic as Everton's recent home success against Chelsea and Manchester United but it is matches against the struggling sides that David Moyes' team must win if they are to qualify for Europe once again.
Arteta's form will be vital in that quest.
The result, meanwhile, will surprise few, particularly with such bleak omens for Hull coming into the match.
The Tigers have not won at Goodison Park since the days of rationing in 1952, although some early promise hinted that record could finally change.
Everton's defenders played a hopeless offside trap, leaving Garcia through on goal but his dink was slapped away by an advancing Tim Howard.
That served as a wake-up call to Moyes' side, who surged forward and came within a whisker of taking the lead.
A terrible display all round from Hull. There was no confidence, we were too slow, no shape, no desire and no leader Thaigerfan Leon Osman robbed George Boateng in midfield and fed Yakubu but a calm finish from the Nigerian hit the base of the post.
Hull's defending looked slugged though, and they failed to learn lessons from the let-off.
Yakubu delivered a hanging cross from the left and Arteta volleyed home superbly at the back post, although some slack defending from Everton old boy Barmby allowed the Spaniard all the time in the world.
Yakubu failed to increase the advantage from the spot though.
A cross from Leighton Baines deflected into the area and Kamil Zayatte crudely brought down the Nigerian from behind - although the defender may have got a trace of the ball.
But Yakubu's lazy run-up never looked convincing and Myhill pulled off a simple save low to his right.
Hull wasted little time in taking advantage, as Cairney scored an excellent first Premier League goal.
A free-kick was only half cleared and the midfielder pounced with a wonderful left-foot volley from just outside the area.
Brown bemoans lack of game plan
It was a goal that will live long in the memory for the 19-year-old but Hull were unable to savour the strike for long.
Victor Anichebe crossed from the right to Steven Pienaar and a clever backheel fell perfectly for Arteta to pass home from 12 yards in style.
Everything the Spaniard touched was turning to gold, and goals, and it was no surprise who inspired Everton's third after the break.
A chipped cross looped over Myhill and Garcia, almost laughably, headed into his own net.
The hosts should really have moved further ahead when a fine pass from substitute Donovan was sidefooted over the bar by Yakubu.
But Donovan showed the striker how it should be done, wrapping up victory with a powerful drive on the angle after another teasing cross from the impressive Baines.
Rodwell put the gloss on a fine display by firing home from Donovan's pass late on.
Hull can be grateful at least for the return from injury of Jimmy Bullard but Brown's side are still in the relegation zone. Much will rest on a trip to basement club Portsmouth next weekend.
Everton manager David Moyes: "He (Arteta) did some fantastic stuff. He got into the box and he's improving all the time.
"When he's on form we're a really good team.
"I was a bit worried when it went to 1-1. I thought it might be one of those days but thankfully we went on to win it."
Hull boss Phil Brown: "I thought we were competitive in the first half but in the second we certainly weren't. We left our game in the changing room for whatever reason.
"Everton were good but we made them look good because we didn't get in the face of the opposition.
"Defensively I have questioned one or two but we will dust ourselves down and get on with it. We have got 10 big games now."
Live text and stats
Sunday, 7 March 2010
Home Team Score Away Team Time Everton 5-1 Hull FT (HT 2-1) Arteta 17 Arteta 39 Garcia (og) 51 Donovan 82 Rodwell 86 Carney 32 Everton 24 Howard 03 Baines 05 Heitinga 06 Jagielka 15 Distin 18 Neville 10 Arteta 20 Pienaar (Gosling 85) 21 Osman (Rodwell 44) 22 Yakubu 28 Anichebe (Donovan 70) Substitutes 01 Nash, 02 Hibbert, 04 Yobo, 07 Bilyaletdinov, 09 Donovan, 19 Gosling, 26 Rodwell Hull 01 Myhill 06 McShane 19 Mouyokolo 24 Zayatte 08 Barmby (Geovanni 60) 17 Kilbane 20 Boateng 21 Bullard (Altidore 62) 45 Carney 14 Garcia yellow card 30 Zaki (Vennegoor of Hesselink 69) Substitutes 12 Duke, 35 Cooper, 10 Geovanni, 23 Ghilas, 44 Olofinjana, 09 Altidore, 29 Vennegoor of Hesselink Ref: Lee MasonAtt: 34,682 EVERTON HULL Possession Everton 50% Hull 50% Attempts on target Everton 1 Hull 2 Attempts off target Everton 4 Hull 1 Corners Everton 0 Hull 0 Fouls Everton 3 Hull 6 Full Time 90:00+3:10 The referee ends the match. 90:00+1:09 Direct effort from the free kick comes in from Johnny Heitinga. 90:00+1:09 Booking Richard Garcia is cautioned. 90:00+0:52 Free kick awarded for a foul by Richard Garcia on Dan Gosling. 88:53 Foul by Jan Vennegoor of Hesselink on Phil Jagielka, free kick awarded. Johnny Heitinga takes the direct free kick. 88:08 Dan Gosling fouled by Paul McShane, the ref awards a free kick. Free kick taken by Mikel Arteta. 87:18 Free kick awarded for a foul by Tom Cairney on Dan Gosling. Mikel Arteta takes the direct free kick. 85:43 Assist by Landon Donovan. 85:43 GOAL - Jack Rodwell:Everton 5 - 1 Hull Jack Rodwell fires in a goal from inside the box to the bottom right corner of the goal. Everton 5-1 Hull. 84:58 Substitution Dan Gosling comes on in place of Steven Pienaar. 82:57 Mikel Arteta gives away a free kick for an unfair challenge on Paul McShane. Boaz Myhill takes the free kick. 81:13 Assist on the goal came from Leighton Baines. 81:13 GOAL - Landon Donovan:Everton 4 - 1 Hull Landon Donovan fires in a goal from inside the penalty area to the bottom left corner of the goal. Everton 4-1 Hull. 76:56 Leighton Baines challenges Richard Garcia unfairly and gives away a free kick. Boaz Myhill takes the direct free kick. 75:13 Sylvain Distin challenges Jozy Altidore unfairly and gives away a free kick. Free kick taken by Tom Cairney. Paul McShane takes a shot. Save made by Tim Howard. 73:15 Ayegbeni Yakubu produces a left-footed shot from inside the area that clears the bar. 69:31 Substitution Victor Anichebe leaves the field to be replaced by Landon Donovan. 67:42 Free kick taken by Phil Jagielka. 67:42 Substitution Jan Vennegoor of Hesselink replaces Amr Zaki. 67:42 Amr Zaki gives away a free kick for an unfair challenge on Sylvain Distin. 67:18 Ayegbeni Yakubu takes a shot. Boaz Myhill makes a comfortable save. 66:33 Unfair challenge on Deiberson Geovanni by Jack Rodwell results in a free kick. Free kick crossed by Deiberson Geovanni, Mikel Arteta makes a clearance. 64:53 Unfair challenge on Paul McShane by Steven Pienaar results in a free kick. Centre by Tom Cairney, Header from close range by Kamil Zayatte clears the bar. 62:53 Johnny Heitinga takes a shot. Blocked by Steven Mouyokolo. 62:30 Sylvain Distin takes a shot. Save by Boaz Myhill. Short corner taken by Mikel Arteta. 61:36 Free kick taken by Phil Neville. 61:36 Substitution Jozy Altidore joins the action as a substitute, replacing Jimmy Bullard. 61:36 Mikel Arteta fouled by Deiberson Geovanni, the ref awards a free kick. 59:02 Substitution Deiberson Geovanni joins the action as a substitute, replacing Nick Barmby. 56:38 Mikel Arteta takes a inswinging corner from the left by-line played to the near post, clearance by Tom Cairney. 56:19 Jack Rodwell takes a shot. Blocked by Tom Cairney. 55:14 Inswinging corner taken right-footed by Jimmy Bullard played to the near post, save made by Tim Howard. 53:46 Unfair challenge on Steven Pienaar by George Boateng results in a free kick. Johnny Heitinga restarts play with the free kick. 50:40 Short corner taken by Mikel Arteta from the left by-line. 50:38 The assist for the goal came from Mikel Arteta. 50:38 GOAL - Richard Garcia:Everton 3 - 1 Hull Headed own goal by Richard Garcia. Everton 3-1 Hull. Correction - 50:36 Corner taken short by Mikel Arteta. 50:08 Phil Neville takes a shot. Blocked by Nick Barmby. Jack Rodwell takes a shot. Save by Boaz Myhill. 48:01 Foul by Steven Mouyokolo on Mikel Arteta, free kick awarded. Free kick crossed by Leighton Baines, Steven Mouyokolo manages to make a clearance. 47:28 Ayegbeni Yakubu is ruled offside. Boaz Myhill takes the indirect free kick. 46:31 Inswinging corner taken left-footed by Leighton Baines from the right by-line to the near post, Richard Garcia manages to make a clearance. 45:28 Foul by George Boateng on Steven Pienaar, free kick awarded. Mikel Arteta fires a strike on goal direct from the free kick. 45:01 The second half has started. Half Time 45:00+3:30 The first half comes to an end. 45:00+1:49 Amr Zaki concedes a free kick for a foul on Sylvain Distin. Direct free kick taken by Tim Howard. 43:51 Substitution (Everton) makes a substitution, with Jack Rodwell coming on for Leon Osman. 42:37 Victor Anichebe fouled by Kevin Kilbane, the ref awards a free kick. Phil Neville takes the free kick. 41:57 Effort on goal by Richard Garcia from just outside the penalty area goes harmlessly over the target. 38:05 Assist on the goal came from Steven Pienaar. 38:05 GOAL - Mikel Arteta:Everton 2 - 1 Hull A goal is scored by Mikel Arteta from deep inside the penalty area to the bottom right corner of the goal. Everton 2-1 Hull. 36:07 Free kick awarded for a foul by Phil Neville on Nick Barmby. Free kick taken by Boaz Myhill. 34:17 Free kick awarded for a foul by George Boateng on Steven Pienaar. Mikel Arteta takes the direct free kick. 32:25 Unfair challenge on Johnny Heitinga by Tom Cairney results in a free kick. Mikel Arteta takes the free kick. 31:17 GOAL - Tom Cairney:Everton 1 - 1 Hull Tom Cairney finds the net with a brilliant goal from the edge of the penalty box to the bottom right corner of the goal. Everton 1-1 Hull. 30:50 Phil Jagielka gives away a free kick for an unfair challenge on Amr Zaki. Jimmy Bullard sends in a cross, 30:01 Ayegbeni Yakubu challenges George Boateng unfairly and gives away a free kick. Kamil Zayatte takes the free kick. 29:16 Shot from just outside the box by Leon Osman goes over the crossbar. 27:52 Penalty taken by Ayegbeni Yakubu is saved by Boaz Myhill. Everton 1-0 Hull. 27:52 Unfair challenge on Ayegbeni Yakubu by Kamil Zayatte results in a Penalty. 25:36 Free kick awarded for a foul by Ayegbeni Yakubu on Jimmy Bullard. Boaz Myhill restarts play with the free kick. 24:43 Mikel Arteta fouled by Kevin Kilbane, the ref awards a free kick. Phil Jagielka takes the direct free kick. 24:01 Victor Anichebe challenges Kevin Kilbane unfairly and gives away a free kick. Direct free kick taken by Boaz Myhill. 22:35 Free kick awarded for a foul by Amr Zaki on Johnny Heitinga. Phil Jagielka restarts play with the free kick. 21:30 Free kick awarded for an unfair challenge on Steven Pienaar by George Boateng. Mikel Arteta restarts play with the free kick. 20:12 Volleyed left-footed shot by Steven Pienaar. Steven Mouyokolo manages to make a clearance. 19:20 Foul by Richard Garcia on Steven Pienaar, free kick awarded. Johnny Heitinga restarts play with the free kick. 18:51 Nick Barmby takes a shot. Phil Neville gets a block in. 16:40 The assist for the goal came from Ayegbeni Yakubu. 16:40 GOAL - Mikel Arteta:Everton 1 - 0 Hull Mikel Arteta grabs a goal from close range to the top right corner of the goal. Everton 1-0 Hull. 14:52 Victor Anichebe fouled by George Boateng, the ref awards a free kick. Mikel Arteta takes the free kick. 12:47 Steven Pienaar fouled by Paul McShane, the ref awards a free kick. Direct free kick taken by Leighton Baines. 12:11 Ayegbeni Yakubu produces a left-footed shot from just inside the box and strikes the post. 11:15 Amr Zaki produces a left-footed shot from just outside the box that goes wide right of the target. 10:42 Shot from outside the box by Mikel Arteta misses to the left of the target. 9:19 Shot from just outside the area by Mikel Arteta misses to the right of the target. 8:40 Free kick awarded for an unfair challenge on Kamil Zayatte by Ayegbeni Yakubu. Boaz Myhill takes the direct free kick. 5:26 Victor Anichebe concedes a free kick for a foul on Kamil Zayatte. Boaz Myhill takes the direct free kick. 5:08 Richard Garcia has a volleyed shot. Save made by Tim Howard. 4:18 Victor Anichebe fouled by Kamil Zayatte, the ref awards a free kick. Free kick taken by Phil Jagielka. 0:00 The ref blows the whistle to begin the match. Live text and data provided by The Press Association.