Shire's ranks depleted
East Stirling are missing the injured Chris Townsley and Ross Gilmour when Annan come calling.
Townsley (knee) and Gilmour (foot) will be joined by David McKenna, who is also absent due to family commitments.
After winning their opening league game against East Fife, the Shire went down 4-0 at Elgin last weekend and head coach Craig Tully is looking for a better display defensively from his men.
Tully explained: "We were doing well at Borough Briggs however we then made poor mistakes at the back and got punished. We cannot keep doing that as it has happened a few times in the past as well. Annan are playing well and do not need any encouragement from us."
Annan are missing only defender Peter Watson, who is serving the second game of a two-match suspension.
Manager Jim Chapman has told his players to be wary of their hosts.
Chapman explained: "East Stirling are a strong side at home as their recent win over East Fife showed. We have hit a good standard in our games so far this season and have given both Queen of the South and St Mirren a hard time in cup competitions.
"The players know that if they maintain that they have a good chance every time they play. If they let it slip then we will be facing a very tough afternoon indeed."