Derby midfield trio Kris Commons, Robbie Savage and new signing Lee Croft have been passed fit.But last season's top scorer Rob Hulse (groin), Shaun Barker (thigh), Chris Porter (hip) and long-term absentee Dean Leacock have all been ruled out.
Peterborough striker Craig Mackail-Smith (groin) and midfielder Dean Keates (Achilles) are in the squad, but Chris Whelpdale (hernia) is out.
Tommy Rowe and Toumani Diagouraga are expected to make their debuts.
The sons of two legendary bosses go head-to-head, with both men building an impressive reputation as managers in their own right.
Having steered Burton Albion towards the League, Nigel Clough kept Derby in the Championship last season and now begins his first full campaign in charge.
Darren Ferguson has back-to-back promotions to his name, and now has the task of establishing Peterborough in the Championship. Ferguson believes strikers Craig Mackail-Smith and Aaron McLean can be prolific at this level. Derby must also be wary of highly-rated winger George Boyd.
• Derby and Peterborough are meeting for the first time in 15 years.
• These clubs have only met four times in the league - all at this level. Posh have won two, lost one and drawn one.
• The Rams are one of three Football League founder members playing Championship football this season. The others are Preston and West Brom.
• It is seven years since Derby last won their opening league fixture (3-0 at home to Reading in 2002).
• Posh are returning to the second tier for the first time in 15 years and this is only their third season at this level.
• A loss for Peterborough would be the 500th away league defeat in their history.
• Lee Frecklington will be hoping to make the 100th start of his league career.
• A goal for Dean Keates would be the 50th of his league career.
MOST RECENT MEETING
Peterborough 2-2 Derby 16 March 1994
Peterborough scorers: Charlery, Iorfa.
Derby scorers: Johnson, Nicholson.