The Irish defender had surgery last month and is not expected to return for the Eagles until March.
Full-back Butterfield is set to miss out with a muscle strain.
The 30-year-old picked up the injury during the 2-0 defeat to Sheffield United two weeks ago and subsequently missed last Saturday's draw with Barnsley.
Meanwhile, former Derby defender Claude Davis is walking a disciplinary tightrope heading into the game, as he has picked up four yellow cards this season and one more will result in a one-match suspension.
Kick-off is at 1pm.